Pathophysiology
Essential hypertension
(m/c)
heredity, age, race, obesity, amount of dietary sodium,
Prehypertension
- Change in contractile properties of smooth muscle in arterial wall?
- Failure of autoregulatory mechanism --> chronically elevated BP --> alterations of arterial smooth muscle?
RAAS
Renal disease
Arterial disease, sleep apnea, pheochromocytoma, glucocorticoids, thyroid/parathyroid disease, other causes
large amounts of tyramine: episodic hypertension
대개 일시적. MAO에 의해 tyramine은 빨리 분해됨. MAOI 때문에 지속될 수 있음.
MAOI \(\ni\) meperidine, amphetamines, ephedrine, reserpine, guanethidine, TCAs
\(\alpha\)-blocker (eg, phentoalmine)로 조절 가능.
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